In this episode of The Histamine Well, Joanne dives deep into Premenstrual Dysphoric Disorder (PMDD) and severe PMS — the kind that can leave you feeling anxious, depressed, exhausted, and unlike yourself for half the month.
Joanne shares insights from her clinical practice to explore what’s really going on beneath the surface, including:
Hormone imbalances like estrogen dominance and low progesterone
Inflammation, oxidative stress, and their impact on ovulation
Nutrient deficiencies that affect mood and hormone function
The surprising role of methylation imbalances — particularly overmethylation — and how this biochemical pathway can disrupt neurotransmitters and mood
She also introduces the concept of testing methylation in real time, and shares a powerful patient story that shows how personalized treatment can dramatically improve mood and cycle symptoms.
Whether you’ve been diagnosed with PMDD or you just know your PMS isn’t normal, this episode offers a fresh perspective and hope for more stable cycles and moods.
🎧 You can also listen to the full episode on Spotify and Apple Podcasts!
Listen on Apple Podcast: https://podcasts.apple.com/us/podcast/histamine-well-podcast-exploring-histamine-methylation/id1797450917
Listen Spotify: https://open.spotify.com/show/4kroSB6Bn4DLLGgKWbQTjq
Tired of treating symptoms instead of the root cause? 🎧
Join Joanne as she unpacks histamine intolerance, methylation, mold illness, and more—so you can finally feel calm, clear, and in control of your health.
✨ Want more? Follow on Instagram and Facebook for updates and tips.
IG: https://www.instagram.com/joannekennedynaturopath/
FB: https://www.facebook.com/Joannekennedynaturopathy1
📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
Link here: https://joannekennedynaturopathy.com/the-ultimate-bundle-for-managing-histamine-intolerance-2/
🎓 Practitioner or student? Explore the Histamine & Methylation Online Group Coaching Course and learn how to confidently work with complex histamine & methylation cases.
Link here: https://joanne-kennedy.mykajabi.com/hmc-application
📆 Work with us one on one. Book a consultation and take your first step to real healing.
Link here: https://joannekennedynaturopathy.com/consultations/
🎤 Have a topic suggestion?
Submit it here: https://joannekennedynaturopathy.com/ask-a-question-or-suggest-a-topic/
🎥 On-Demand Webinars – Now 20% Off!
Oestrogen, Hormonal Imbalance & Histamine
Learn how oestrogen and progesterone affect your mood, histamine levels, and overall well-being in this 40-minute webinar. Includes key signs of hormonal imbalance, detox pathways, and supplement support. Use code HORMONES for 20% off!
👉 https://joannekennedynaturheilkunde.de/products/hormones?utm_source=copyToPasteBoard&utm_medium=product-links&utm_content=web
Histamine & Oxalates
Discover how oxalates drive inflammation, histamine overload, and nutrient depletion in this 45-minute session. Learn practical strategies to reduce oxalates safely. Use code OXALATES for 20% off!
👉 https://joannekennedynaturheilkunde.de/products/oxalates?utm_source=copyToPasteBoard&utm_medium=product-links&utm_content=web
🧬 Methylation Testing
In just 15 minutes, discover if you’re over- or under-methylating with the only at-home saliva test for methylation. Get instant results plus supplement recommendations to help restore balance. Joanne highly recommends this test and has secured a 10% discount for podcast listeners. Use code HISTAMINEWELL10 at checkout—for your first and all future orders.
👉https://joannekennedynaturopathy.com/methylation-test/
Time stamps:
00:00 Introduction to PMDD and Severe PMS
01:31 Understanding PMDD: Symptoms and Diagnosis
02:35 Cycle Regularity and Hormonal Balance
04:34 Addressing Estrogen Dominance
06:06 Supporting Progesterone Production
07:00 Inflammation, Oxidative Stress, and Follicle Health
07:53 The Role of Methylation in Mood Stability
10:56 Case Study: Managing Complex PMDD
13:18 Conclusion and Final Thoughts
#pmdd #pms #hormonalimbalance #oxidativestress #methylation


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